This gene is a member of the beta-1,4-galactosyltransferase (beta4GalT) family. Family members encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose. Each beta4GalT member has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus which then remains uncleaved to function as a transmembrane anchor. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein linkage (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) found in proteoglycans. This enzyme differs from other beta4GalTs because it lacks the conserved Cys residues found in beta4GalT1-beta4GalT6 and it is located in cis-Golgi instead of trans-Golgi. Mutations in this gene have been associated with the progeroid form of Ehlers-Danlos syndrome. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for B4GALT7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = B4GALT7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of B4GALT7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:177,303,008–177,304,238 | 296.4 kb | Distal (>10kb) Multiome | 850 | |
| chr5:177,309,549–177,310,172 | 290.3 kb | Distal (>10kb) Multiome | 373 | |
| chr5:177,311,267–177,313,178 | 287.9 kb | Distal (>10kb) Multiome | 798 | |
| chr5:177,351,374–177,352,243 | 248.3 kb | Distal (>10kb) Multiome | 832 | |
| chr5:177,362,756–177,363,624 | 236.9 kb | Distal (>10kb) Multiome | 479 | |
| chr5:177,366,082–177,368,548 | 232.9 kb | Distal (>10kb) Multiome | 626 | |
| chr5:177,370,255–177,371,449 | 229.2 kb | Distal (>10kb) Multiome | 584 | |
| chr5:177,402,327–177,404,671 | 195.7 kb | Distal (>10kb) Multiome | 807 | |
| chr5:177,425,334–177,427,296 | 173.7 kb | Distal (>10kb) Multiome | 982 | |
| chr5:177,446,196–177,448,203 | 153.4 kb | Distal (>10kb) Multiome | 826 | |
| chr5:177,453,910–177,456,838 | 144.6 kb | Distal (>10kb) Multiome | 1057 | |
| chr5:177,457,280–177,458,365 | 142.3 kb | Distal (>10kb) Multiome | 321 | |
| chr5:177,472,252–177,474,487 | 127.4 kb | Distal (>10kb) Multiome | 546 | |
| chr5:177,491,301–177,491,987 | 108.5 kb | Distal (>10kb) Multiome | 522 | |
| chr5:177,494,661–177,498,477 | 104.5 kb | Distal (>10kb) Multiome | 915 | |
| chr5:177,500,863–177,501,460 | 99.0 kb | Distal (>10kb) Multiome | 378 | |
| chr5:177,516,515–177,517,551 | 83.0 kb | Distal (>10kb) Multiome | 958 | |
| chr5:177,553,719–177,554,931 | 45.5 kb | Distal (>10kb) Multiome | 671 | |
| chr5:177,591,993–177,592,765 | 7.9 kb | Proximal (<10kb) Multiome | 724 | |
| chr5:177,599,409–177,600,500 | 49 bp | At TSS Multiome | 871 | |
| chr5:177,607,310–177,608,120 | 7.5 kb | Proximal (<10kb) Multiome | 392 |
Genomic view of the B4GALT7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.