This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase protein family. The encoded enzyme is involved in the biosynthesis of poly-N-acetyllactosamine chains and prefers lacto-N-neotetraose as a substrate. It is a type II transmembrane protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for B3GNT4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = B3GNT4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of B3GNT4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:121,918,184–121,919,001 | 285.1 kb | Distal (>10kb) Multiome | 407 | |
| chr12:122,021,348–122,022,698 | 181.7 kb | Distal (>10kb) Multiome | 537 | |
| chr12:122,063,787–122,064,537 | 139.5 kb | Distal (>10kb) Multiome | 742 | |
| chr12:122,078,081–122,079,394 | 125.0 kb | Distal (>10kb) Multiome | 952 | |
| chr12:122,097,641–122,098,611 | 105.6 kb | Distal (>10kb) Multiome | 462 | |
| chr12:122,155,564–122,156,340 | 47.7 kb | Distal (>10kb) Multiome | 197 | |
| chr12:122,182,856–122,183,527 | 20.5 kb | Distal (>10kb) Multiome | 228 | |
| chr12:122,203,186–122,204,669 | 38 bp | At TSS Multiome | 500 | |
| chr12:122,225,485–122,227,116 | 22.5 kb | Distal (>10kb) Multiome | 1019 | |
| chr12:122,265,933–122,267,109 | 62.9 kb | Distal (>10kb) Multiome | 1060 | |
| chr12:122,421,844–122,422,754 | 218.7 kb | Distal (>10kb) Multiome | 685 | |
| chr12:122,500,206–122,501,493 | 297.3 kb | Distal (>10kb) Multiome | 955 |
Genomic view of the B3GNT4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.