Predicted to be involved in manchette assembly. Located in ciliary basal body and cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AXDND1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AXDND1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AXDND1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:179,081,467–179,083,301 | 283.7 kb | Distal (>10kb) Multiome HiCAR | 968 | |
| chr1:179,228,751–179,230,142 | 136.0 kb | Distal (>10kb) Multiome | 634 | |
| chr1:179,293,131–179,294,199 | 72.0 kb | Distal (>10kb) Multiome | 884 | |
| chr1:179,365,435–179,366,459 | 150 bp | At TSS Multiome | 811 | |
| chr1:179,369,845–179,370,044 | 4.1 kb | Proximal (<10kb) | 118 | |
| chr1:179,586,188–179,586,937 | 220.7 kb | Distal (>10kb) Multiome | 413 | |
| chr1:179,591,348–179,592,445 | 226.2 kb | Distal (>10kb) Multiome | 401 |
Genomic view of the AXDND1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.