Predicted to be involved in positive regulation of MAPK cascade. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AVPI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AVPI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AVPI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:97,400,817–97,401,691 | 285.9 kb | Distal (>10kb) Multiome | 644 | |
| chr10:97,407,246–97,407,739 | 279.8 kb | Distal (>10kb) Multiome | 539 | |
| chr10:97,418,830–97,419,461 | 268.1 kb | Distal (>10kb) Multiome | 323 | |
| chr10:97,425,050–97,426,796 | 261.1 kb | Distal (>10kb) Multiome | 715 | |
| chr10:97,445,521–97,446,585 | 241.1 kb | Distal (>10kb) Multiome | 802 | |
| chr10:97,497,718–97,499,773 | 188.6 kb | Distal (>10kb) Multiome | 967 | |
| chr10:97,553,598–97,554,047 | 133.5 kb | Distal (>10kb) Multiome | 340 | |
| chr10:97,632,775–97,633,915 | 53.7 kb | Distal (>10kb) Multiome | 725 | |
| chr10:97,640,236–97,641,335 | 46.6 kb | Distal (>10kb) Multiome | 712 | |
| chr10:97,685,703–97,685,886 | 1.4 kb | Proximal (<10kb) | 216 | |
| chr10:97,686,724–97,687,987 | 159 bp | At TSS Multiome | 993 | |
| chr10:97,713,223–97,715,263 | 27.8 kb | Distal (>10kb) Multiome | 639 | |
| chr10:97,736,595–97,737,824 | 49.9 kb | Distal (>10kb) Multiome HiCAR | 1009 | |
| chr10:97,771,123–97,772,389 | 84.5 kb | Distal (>10kb) Multiome | 356 | |
| chr10:97,849,566–97,850,474 | 162.8 kb | Distal (>10kb) Multiome | 400 |
Genomic view of the AVPI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.