Transcription factors with Perturb-seq knockdown data for ATXN1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATXN1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATXN1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:16,758,245–16,758,900 | 3.0 kb | Proximal (<10kb) | 233 | |
| chr6:16,759,726–16,763,021 | at TSS | At TSS | 1093 | |
| chr6:16,763,130–16,763,384 | 1.2 kb | Proximal (<10kb) | 299 | |
| chr6:16,771,013–16,771,264 | 9.1 kb | Proximal (<10kb) | 394 |
Genomic view of the ATXN1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.