ATRAID
all-trans retinoic acid induced differentiation factor | APR3, HSPC013, p18, C2orf28

This gene is thought to be involved in apoptosis, and may also be involved in hematopoietic development and differentiation. The use of alternative splice sites and promotors result in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2009]

Member of: DE-1
Biological processes 18 terms
intracellular membrane-bounded organelle (GO:0043231)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)negative regulation of osteoblast proliferation (GO:0033689)negative regulation of protein catabolic process (GO:0042177)nuclear envelope (GO:0005635)nuclear envelope (GO:0005635)perinuclear region of cytoplasm (GO:0048471)plasma membrane (GO:0005886)positive regulation of bone mineralization (GO:0030501)positive regulation of osteoblast differentiation (GO:0045669)positive regulation of osteoblast differentiation (GO:0045669)protein binding (GO:0005515)regulation of gene expression (GO:0010468)xenobiotic transmembrane transport (GO:0006855)xenobiotic transmembrane transport (GO:0006855)xenobiotic transmembrane transporter activity (GO:0042910)xenobiotic transmembrane transporter activity (GO:0042910)
Expression (TPM)
ATRAID — as a Regulated Gene

TFs regulating ATRAID 0 TFs

Transcription factors with Perturb-seq knockdown data for ATRAID. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATRAID upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ATRAID

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATRAID, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr2:26,961,589–26,962,066 250.1 kb Distal (>10kb) Multiome 502
chr2:26,970,294–26,971,331 241.5 kb Distal (>10kb) Multiome 572
chr2:27,032,577–27,033,271 179.1 kb Distal (>10kb) Multiome 799
chr2:27,049,564–27,052,299 161.3 kb Distal (>10kb) Multiome 1295
chr2:27,071,223–27,072,896 140.3 kb Distal (>10kb) Multiome 864
chr2:27,081,006–27,081,641 130.7 kb Distal (>10kb) Multiome 758
chr2:27,085,591–27,087,452 125.4 kb Distal (>10kb) Multiome 970
chr2:27,123,498–27,124,089 88.2 kb Distal (>10kb) Multiome 553
chr2:27,133,917–27,135,216 77.4 kb Distal (>10kb) Multiome 815
chr2:27,211,255–27,212,840 88 bp At TSS Multiome 978
chr2:27,217,045–27,218,005 5.4 kb Proximal (<10kb) Multiome 771
chr2:27,250,040–27,250,883 38.4 kb Distal (>10kb) Multiome 559
chr2:27,262,260–27,263,337 50.9 kb Distal (>10kb) Multiome 376
chr2:27,264,406–27,265,326 53.1 kb Distal (>10kb) Multiome 696
chr2:27,306,488–27,307,261 94.6 kb Distal (>10kb) Multiome 115
chr2:27,322,773–27,323,423 111.1 kb Distal (>10kb) Multiome 906
chr2:27,356,094–27,357,596 144.9 kb Distal (>10kb) Multiome 1084
chr2:27,369,685–27,371,261 158.4 kb Distal (>10kb) Multiome 1096
chr2:27,380,026–27,381,202 168.7 kb Distal (>10kb) Multiome 821
chr2:27,408,972–27,410,056 197.6 kb Distal (>10kb) Multiome 989
chr2:27,428,202–27,429,633 216.6 kb Distal (>10kb) Multiome 1013
chr2:27,441,811–27,442,884 230.4 kb Distal (>10kb) Multiome 380
chr2:27,489,334–27,490,205 277.8 kb Distal (>10kb) Multiome 731
chr2:27,494,797–27,495,577 283.2 kb Distal (>10kb) Multiome 380

Genome Browser

Genomic view of the ATRAID locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr2:26,951,589 – 27,505,577
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact