Enables P-type calcium transporter activity and P-type manganese transporter activity. Predicted to be involved in calcium ion transmembrane transport; intracellular calcium ion homeostasis; and manganese ion transport. Predicted to act upstream of or within mammary gland epithelium development; positive regulation of calcium ion import; and protein localization to plasma membrane. Predicted to be located in trans-Golgi network membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ATP2C2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP2C2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP2C2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:84,116,331–84,117,716 | 251.6 kb | Distal (>10kb) Multiome | 1013 | |
| chr16:84,144,637–84,145,742 | 223.4 kb | Distal (>10kb) Multiome | 679 | |
| chr16:84,186,615–84,187,246 | 181.5 kb | Distal (>10kb) Multiome | 848 | |
| chr16:84,367,919–84,368,944 | 86 bp | At TSS Multiome | 287 | |
| chr16:84,504,051–84,505,316 | 136.2 kb | Distal (>10kb) Multiome | 803 | |
| chr16:84,617,446–84,619,117 | 249.7 kb | Distal (>10kb) Multiome | 844 | |
| chr16:84,648,019–84,649,061 | 280.0 kb | Distal (>10kb) Multiome | 797 |
Genomic view of the ATP2C2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.