The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for ATP23. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP23 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP23, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:57,693,486–57,694,647 | 247.6 kb | Distal (>10kb) Multiome | 757 | |
| chr12:57,726,079–57,726,879 | 215.3 kb | Distal (>10kb) Multiome | 597 | |
| chr12:57,738,612–57,739,176 | 202.5 kb | Distal (>10kb) Multiome | 201 | |
| chr12:57,744,434–57,745,735 | 196.6 kb | Distal (>10kb) Multiome | 822 | |
| chr12:57,751,806–57,753,147 | 189.1 kb | Distal (>10kb) Multiome | 1030 | |
| chr12:57,754,455–57,756,188 | 186.6 kb | Distal (>10kb) Multiome | 616 | |
| chr12:57,756,649–57,757,193 | 184.6 kb | Distal (>10kb) Multiome | 315 | |
| chr12:57,765,020–57,765,720 | 176.2 kb | Distal (>10kb) Multiome | 472 | |
| chr12:57,766,452–57,767,514 | 174.5 kb | Distal (>10kb) Multiome | 330 | |
| chr12:57,771,528–57,773,018 | 169.4 kb | Distal (>10kb) Multiome | 1006 | |
| chr12:57,782,579–57,783,204 | 158.8 kb | Distal (>10kb) Multiome | 916 | |
| chr12:57,814,980–57,815,520 | 126.3 kb | Distal (>10kb) Multiome | 117 | |
| chr12:57,844,422–57,847,797 | 94.5 kb | Distal (>10kb) Multiome | 1032 | |
| chr12:57,852,281–57,853,469 | 88.7 kb | Distal (>10kb) Multiome | 295 | |
| chr12:57,865,060–57,865,767 | 76.1 kb | Distal (>10kb) Multiome | 547 | |
| chr12:57,888,522–57,889,064 | 53.0 kb | Distal (>10kb) Multiome | 328 | |
| chr12:57,896,473–57,897,915 | 44.6 kb | Distal (>10kb) Multiome | 419 | |
| chr12:57,935,860–57,936,461 | 5.4 kb | Proximal (<10kb) Multiome | 650 | |
| chr12:57,940,778–57,942,227 | 44 bp | At TSS Multiome | 836 | |
| chr12:58,139,396–58,140,263 | 198.4 kb | Distal (>10kb) Multiome | 150 | |
| chr12:58,206,630–58,207,741 | 265.6 kb | Distal (>10kb) Multiome | 155 |
Genomic view of the ATP23 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.