ATP1B2

ATPase Na+/K+ transporting subunit beta 2 | AMOG

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Biological processes 73 terms

ATPase activator activity (GO:0001671)ATPase activator activity (GO:0001671)ATPase activator activity (GO:0001671)ATPase binding (GO:0051117)ATPase binding (GO:0051117)apical plasma membrane (GO:0016324)apical plasma membrane (GO:0016324)astrocyte end-foot (GO:0097450)astrocyte end-foot (GO:0097450)astrocyte projection (GO:0097449)astrocyte projection (GO:0097449)astrocyte projection (GO:0097449)cell body membrane (GO:0044298)cell body membrane (GO:0044298)cell communication by electrical coupling involved in cardiac conduction (GO:0086064)cell periphery (GO:0071944)cell projection membrane (GO:0031253)cell projection membrane (GO:0031253)cell-substrate adhesion (GO:0031589)cell-substrate adhesion (GO:0031589)cytoplasm (GO:0005737)external side of plasma membrane (GO:0009897)external side of plasma membrane (GO:0009897)intracellular potassium ion homeostasis (GO:0030007)intracellular potassium ion homeostasis (GO:0030007)intracellular potassium ion homeostasis (GO:0030007)intracellular sodium ion homeostasis (GO:0006883)intracellular sodium ion homeostasis (GO:0006883)intracellular sodium ion homeostasis (GO:0006883)lateral plasma membrane (GO:0016328)lateral ventricle development (GO:0021670)membrane (GO:0016020)membrane repolarization (GO:0086009)membrane repolarization (GO:0086009)motor behavior (GO:0061744)negative regulation of glial cell migration (GO:1903976)negative regulation of glial cell migration (GO:1903976)neuron to neuron synapse (GO:0098984)neuron to neuron synapse (GO:0098984)neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration (GO:0021944)photoreceptor cell maintenance (GO:0045494)photoreceptor inner segment (GO:0001917)photoreceptor inner segment (GO:0001917)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane bounded cell projection organization (GO:0120036)positive regulation of neuron projection development (GO:0010976)positive regulation of neuron projection development (GO:0010976)positive regulation of potassium ion import across plasma membrane (GO:1903288)positive regulation of potassium ion import across plasma membrane (GO:1903288)positive regulation of sodium ion export across plasma membrane (GO:1903278)positive regulation of sodium ion export across plasma membrane (GO:1903278)potassium ion import across plasma membrane (GO:1990573)potassium ion import across plasma membrane (GO:1990573)potassium ion import across plasma membrane (GO:1990573)potassium ion transport (GO:0006813)protein binding (GO:0005515)protein stabilization (GO:0050821)protein-macromolecule adaptor activity (GO:0030674)retina homeostasis (GO:0001895)sodium ion export across plasma membrane (GO:0036376)sodium ion export across plasma membrane (GO:0036376)sodium ion export across plasma membrane (GO:0036376)sodium ion transport (GO:0006814)sodium:potassium-exchanging ATPase complex (GO:0005890)sodium:potassium-exchanging ATPase complex (GO:0005890)sodium:potassium-exchanging ATPase complex (GO:0005890)sodium:potassium-exchanging ATPase complex (GO:0005890)third ventricle development (GO:0021678)transport across blood-brain barrier (GO:0150104)transporter activator activity (GO:0141109)transporter activator activity (GO:0141109)

Expression (TPM)

TFs regulating ATP1B2 0 TFs

Transcription factors with Perturb-seq knockdown data for ATP1B2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP1B2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ATP1B2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP1B2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:7,351,208–7,352,575	298.9 kb	Distal (>10kb) Multiome	857
chr17:7,356,082–7,356,523	294.7 kb	Distal (>10kb) Multiome	485
chr17:7,383,791–7,384,537	266.7 kb	Distal (>10kb) Multiome	218
chr17:7,393,924–7,395,223	256.3 kb	Distal (>10kb) Multiome	744
chr17:7,403,290–7,405,695	246.6 kb	Distal (>10kb) Multiome	838
chr17:7,435,167–7,437,681	213.8 kb	Distal (>10kb) Multiome	828
chr17:7,437,892–7,438,555	212.6 kb	Distal (>10kb) Multiome	224
chr17:7,440,048–7,441,211	210.2 kb	Distal (>10kb) Multiome	487
chr17:7,444,968–7,446,142	205.4 kb	Distal (>10kb) Multiome	632
chr17:7,455,450–7,456,019	195.3 kb	Distal (>10kb) Multiome	414
chr17:7,478,839–7,480,126	171.4 kb	Distal (>10kb) Multiome	574
chr17:7,483,139–7,485,576	166.5 kb	Distal (>10kb) Multiome	1156
chr17:7,548,693–7,549,285	101.9 kb	Distal (>10kb) Multiome	387
chr17:7,560,249–7,562,536	89.0 kb	Distal (>10kb) Multiome	759
chr17:7,572,039–7,574,418	77.0 kb	Distal (>10kb) Multiome	1071
chr17:7,579,018–7,579,876	71.5 kb	Distal (>10kb) Multiome	844
chr17:7,583,063–7,584,547	67.1 kb	Distal (>10kb) Multiome	921
chr17:7,588,871–7,590,534	60.8 kb	Distal (>10kb) Multiome	319
chr17:7,614,065–7,615,780	35.8 kb	Distal (>10kb) Multiome	708
chr17:7,627,090–7,628,247	23.1 kb	Distal (>10kb) Multiome	712
chr17:7,650,010–7,652,127	151 bp	At TSS Multiome	467
chr17:7,656,917–7,657,255	6.0 kb	Proximal (<10kb)	134
chr17:7,685,876–7,686,907	35.4 kb	Distal (>10kb) Multiome	765
chr17:7,687,214–7,687,777	36.6 kb	Distal (>10kb) Multiome	710
chr17:7,687,867–7,688,863	37.4 kb	Distal (>10kb) Multiome	700
chr17:7,703,383–7,703,975	52.7 kb	Distal (>10kb) Multiome	141
chr17:7,704,799–7,705,590	54.2 kb	Distal (>10kb) Multiome	325
chr17:7,716,832–7,717,983	66.4 kb	Distal (>10kb) Multiome	759
chr17:7,833,417–7,837,960	184.7 kb	Distal (>10kb) Multiome	1160
chr17:7,841,438–7,843,228	191.3 kb	Distal (>10kb) Multiome	861
chr17:7,843,355–7,844,130	192.7 kb	Distal (>10kb) Multiome	614
chr17:7,844,349–7,845,186	194.0 kb	Distal (>10kb) Multiome	617
chr17:7,851,538–7,852,239	200.9 kb	Distal (>10kb) Multiome	531
chr17:7,856,600–7,858,747	206.6 kb	Distal (>10kb) Multiome	942
chr17:7,885,205–7,885,734	234.4 kb	Distal (>10kb) Multiome	371
chr17:7,887,616–7,888,198	236.9 kb	Distal (>10kb) Multiome	581
chr17:7,915,430–7,916,499	265.0 kb	Distal (>10kb) Multiome	869
chr17:7,922,863–7,923,421	272.1 kb	Distal (>10kb) Multiome	205
chr17:7,929,559–7,930,172	278.9 kb	Distal (>10kb) Multiome	106
chr17:7,931,533–7,932,876	281.2 kb	Distal (>10kb) Multiome	767

Genome Browser

Genomic view of the ATP1B2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.