The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome, also known as 'happy puppet syndrome'. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ATP10A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATP10A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATP10A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:25,669,944–25,670,594 | 193.5 kb | Distal (>10kb) Multiome | 215 | |
| chr15:25,850,206–25,850,970 | 13.1 kb | Distal (>10kb) Multiome | 318 | |
| chr15:25,862,414–25,863,681 | 717 bp | At TSS Multiome | 212 | |
| chr15:25,933,599–25,934,254 | 70.4 kb | Distal (>10kb) Multiome | 186 | |
| chr15:26,081,757–26,083,232 | 218.7 kb | Distal (>10kb) Multiome | 777 |
Genomic view of the ATP10A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.