Predicted to be involved in autophagosome assembly. Predicted to act upstream of or within negative stranded viral RNA replication. Located in nucleoplasm. Part of Atg12-Atg5-Atg16 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ATG16L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATG16L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATG16L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:72,534,428–72,535,106 | 279.5 kb | Distal (>10kb) Multiome | 152 | |
| chr11:72,584,069–72,584,889 | 229.9 kb | Distal (>10kb) Multiome | 98 | |
| chr11:72,589,653–72,590,682 | 224.1 kb | Distal (>10kb) Multiome | 303 | |
| chr11:72,642,014–72,643,645 | 171.3 kb | Distal (>10kb) Multiome | 594 | |
| chr11:72,683,647–72,685,043 | 130.2 kb | Distal (>10kb) Multiome HiCAR | 428 | |
| chr11:72,722,329–72,722,710 | 91.8 kb | Distal (>10kb) Multiome HiCAR | 323 | |
| chr11:72,752,008–72,752,857 | 61.9 kb | Distal (>10kb) Multiome | 638 | |
| chr11:72,781,427–72,782,186 | 32.6 kb | Distal (>10kb) Multiome | 399 | |
| chr11:72,793,430–72,794,453 | 20.5 kb | Distal (>10kb) Multiome | 847 | |
| chr11:72,812,987–72,813,226 | 1.2 kb | Proximal (<10kb) | 372 | |
| chr11:72,813,727–72,815,115 | 24 bp | At TSS Multiome | 870 | |
| chr11:72,821,008–72,822,837 | 7.9 kb | Proximal (<10kb) Multiome | 628 | |
| chr11:73,141,056–73,143,237 | 328.1 kb | Distal (>10kb) Multiome HiCAR | 1038 | |
| chr11:73,217,837–73,218,810 | 403.9 kb | Distal (>10kb) Multiome HiCAR | 603 |
Genomic view of the ATG16L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.