This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for ASIC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ASIC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ASIC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:33,291,377–33,293,455 | 1.5 kb | Proximal (<10kb) Multiome | 242 | |
| chr17:33,302,443–33,302,650 | 9.1 kb | Proximal (<10kb) | 54 | |
| chr17:33,929,083–33,929,725 | 636.1 kb | Distal (>10kb) Multiome | 100 | |
| chr17:34,156,980–34,157,883 | 864.2 kb | Distal (>10kb) Multiome | 139 | |
| chr17:34,234,023–34,235,018 | 941.2 kb | Distal (>10kb) Multiome | 70 | |
| chr17:34,250,926–34,251,474 | 957.9 kb | Distal (>10kb) Multiome | 18 |
Genomic view of the ASIC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.