ASB9

ankyrin repeat and SOCS box containing 9 | DKFZP564L0862, FLJ20636, MGC4954

This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Biological processes 14 terms

Cul5-RING ubiquitin ligase complex (GO:0031466)cytosol (GO:0005829)cytosol (GO:0005829)intracellular signal transduction (GO:0035556)mitochondrion (GO:0005739)positive regulation of protein catabolic process (GO:0045732)positive regulation of protein catabolic process (GO:0045732)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)ubiquitin-like ligase-substrate adaptor activity (GO:1990756)ubiquitin-like ligase-substrate adaptor activity (GO:1990756)

Expression (TPM)