Predicted to be involved in intracellular signal transduction and protein ubiquitination. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ASB8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ASB8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ASB8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:47,904,573–47,905,755 | 252.4 kb | Distal (>10kb) Multiome | 575 | |
| chr12:47,942,159–47,942,641 | 215.1 kb | Distal (>10kb) Multiome | 160 | |
| chr12:47,963,134–47,964,083 | 194.0 kb | Distal (>10kb) Multiome | 742 | |
| chr12:48,000,982–48,002,307 | 156.0 kb | Distal (>10kb) Multiome | 379 | |
| chr12:48,003,968–48,005,434 | 152.9 kb | Distal (>10kb) Multiome | 366 | |
| chr12:48,021,709–48,022,295 | 135.6 kb | Distal (>10kb) Multiome | 419 | |
| chr12:48,023,364–48,024,084 | 134.0 kb | Distal (>10kb) Multiome | 188 | |
| chr12:48,037,309–48,037,998 | 120.0 kb | Distal (>10kb) Multiome | 157 | |
| chr12:48,105,562–48,106,521 | 51.5 kb | Distal (>10kb) Multiome | 962 | |
| chr12:48,118,916–48,119,822 | 38.2 kb | Distal (>10kb) Multiome | 486 | |
| chr12:48,156,989–48,157,958 | 17 bp | At TSS Multiome | 767 | |
| chr12:48,165,213–48,165,368 | 7.6 kb | Proximal (<10kb) | 116 | |
| chr12:48,183,072–48,184,156 | 25.9 kb | Distal (>10kb) Multiome | 407 | |
| chr12:48,197,601–48,198,835 | 40.7 kb | Distal (>10kb) Multiome | 631 | |
| chr12:48,296,399–48,297,046 | 139.2 kb | Distal (>10kb) Multiome | 297 | |
| chr12:48,350,111–48,351,553 | 193.4 kb | Distal (>10kb) Multiome | 817 |
Genomic view of the ASB8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.