Transcription factors with Perturb-seq knockdown data for ASB16-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ASB16-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ASB16-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:43,900,207–43,900,990 | 286.0 kb | Distal (>10kb) Multiome | 308 | |
| chr17:43,906,025–43,906,856 | 280.1 kb | Distal (>10kb) Multiome | 353 | |
| chr17:43,907,081–43,907,899 | 279.0 kb | Distal (>10kb) Multiome | 362 | |
| chr17:43,937,932–43,938,382 | 248.5 kb | Distal (>10kb) Multiome | 757 | |
| chr17:43,952,298–43,953,752 | 233.6 kb | Distal (>10kb) Multiome | 295 | |
| chr17:43,983,489–43,984,364 | 202.7 kb | Distal (>10kb) Multiome | 743 | |
| chr17:44,004,236–44,007,875 | 182.0 kb | Distal (>10kb) Multiome | 807 | |
| chr17:44,014,255–44,015,168 | 171.8 kb | Distal (>10kb) Multiome | 1020 | |
| chr17:44,066,017–44,066,857 | 120.1 kb | Distal (>10kb) Multiome | 722 | |
| chr17:44,070,107–44,071,340 | 115.9 kb | Distal (>10kb) Multiome | 1041 | |
| chr17:44,095,480–44,096,263 | 90.7 kb | Distal (>10kb) Multiome | 713 | |
| chr17:44,110,949–44,111,605 | 75.4 kb | Distal (>10kb) Multiome | 856 | |
| chr17:44,122,999–44,124,340 | 62.9 kb | Distal (>10kb) Multiome | 883 | |
| chr17:44,141,505–44,142,741 | 44.8 kb | Distal (>10kb) Multiome | 857 | |
| chr17:44,168,259–44,168,849 | 18.1 kb | Distal (>10kb) Multiome | 475 | |
| chr17:44,186,111–44,187,514 | 135 bp | At TSS Multiome | 917 | |
| chr17:44,192,254–44,192,580 | 5.6 kb | Proximal (<10kb) | 98 | |
| chr17:44,198,550–44,201,037 | 13.5 kb | Distal (>10kb) Multiome | 868 | |
| chr17:44,210,257–44,210,930 | 23.9 kb | Distal (>10kb) Multiome | 568 | |
| chr17:44,218,107–44,221,629 | 31.9 kb | Distal (>10kb) Multiome | 936 | |
| chr17:44,221,765–44,222,816 | 35.6 kb | Distal (>10kb) Multiome | 597 | |
| chr17:44,307,755–44,309,164 | 121.8 kb | Distal (>10kb) Multiome | 726 | |
| chr17:44,314,945–44,315,776 | 128.6 kb | Distal (>10kb) Multiome | 273 | |
| chr17:44,316,273–44,316,728 | 129.8 kb | Distal (>10kb) Multiome | 183 | |
| chr17:44,324,218–44,325,841 | 138.2 kb | Distal (>10kb) Multiome | 852 | |
| chr17:44,326,610–44,327,149 | 140.3 kb | Distal (>10kb) Multiome | 599 | |
| chr17:44,344,826–44,346,001 | 158.5 kb | Distal (>10kb) Multiome | 837 | |
| chr17:44,353,667–44,355,182 | 168.0 kb | Distal (>10kb) Multiome | 393 | |
| chr17:44,363,447–44,364,077 | 177.1 kb | Distal (>10kb) Multiome | 502 | |
| chr17:44,374,688–44,375,216 | 188.2 kb | Distal (>10kb) Multiome | 299 | |
| chr17:44,384,542–44,386,175 | 198.8 kb | Distal (>10kb) Multiome | 553 |
Genomic view of the ASB16-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.