Predicted to enable N-acylsphingosine amidohydrolase activity. Predicted to be involved in ceramide catabolic process. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ASAH2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ASAH2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ASAH2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:50,525,999–50,526,990 | 213.6 kb | Distal (>10kb) Multiome | 97 | |
| chr10:50,527,119–50,527,948 | 212.3 kb | Distal (>10kb) Multiome | 184 | |
| chr10:50,552,393–50,553,104 | 187.2 kb | Distal (>10kb) Multiome | 283 | |
| chr10:50,563,679–50,564,552 | 175.8 kb | Distal (>10kb) Multiome | 262 | |
| chr10:50,621,826–50,626,107 | 115.3 kb | Distal (>10kb) Multiome | 1163 | |
| chr10:50,739,446–50,740,529 | 18 bp | At TSS Multiome | 635 | |
| chr10:50,787,771–50,788,455 | 48.1 kb | Distal (>10kb) Multiome | 88 |
Genomic view of the ASAH2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.