ASAH2

N-acylsphingosine amidohydrolase 2

Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]).[supplied by OMIM, Mar 2008]

Biological processes 40 terms

Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)N-acylsphingosine amidohydrolase activity (GO:0017040)N-acylsphingosine amidohydrolase activity (GO:0017040)N-acylsphingosine amidohydrolase activity (GO:0017040)N-acylsphingosine amidohydrolase activity (GO:0017040)calcium ion binding (GO:0005509)caveola (GO:0005901)caveola (GO:0005901)cellular response to cytokine stimulus (GO:0071345)ceramide biosynthetic process (GO:0046513)ceramide biosynthetic process (GO:0046513)ceramide biosynthetic process (GO:0046513)ceramide catabolic process (GO:0046514)ceramide catabolic process (GO:0046514)ceramide catabolic process (GO:0046514)ceramide catabolic process (GO:0046514)ceramide metabolic process (GO:0006672)cytoplasm (GO:0005737)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)lipid digestion (GO:0044241)long-chain fatty acid biosynthetic process (GO:0042759)membrane raft (GO:0045121)membrane raft (GO:0045121)mitochondrion (GO:0005739)mitochondrion (GO:0005739)negative regulation of apoptotic signaling pathway (GO:2001234)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)regulation of mitotic cell cycle (GO:0007346)sphingolipid metabolic process (GO:0006665)sphingosine biosynthetic process (GO:0046512)sphingosine biosynthetic process (GO:0046512)sphingosine biosynthetic process (GO:0046512)sphingosine metabolic process (GO:0006670)sphingosine metabolic process (GO:0006670)zinc ion binding (GO:0008270)

Expression (TPM)