AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for AS3MT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AS3MT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AS3MT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:102,641,824–102,646,130 | 224.4 kb | Distal (>10kb) Multiome | 1123 | |
| chr10:102,678,809–102,679,295 | 190.4 kb | Distal (>10kb) Multiome | 476 | |
| chr10:102,713,669–102,715,337 | 155.1 kb | Distal (>10kb) Multiome | 895 | |
| chr10:102,743,388–102,744,547 | 125.6 kb | Distal (>10kb) Multiome | 777 | |
| chr10:102,776,775–102,777,340 | 92.5 kb | Distal (>10kb) Multiome | 419 | |
| chr10:102,853,920–102,854,718 | 15.1 kb | Distal (>10kb) Multiome | 859 | |
| chr10:102,869,308–102,870,223 | 94 bp | At TSS Multiome | 509 | |
| chr10:102,916,941–102,919,907 | 48.7 kb | Distal (>10kb) Multiome | 984 |
Genomic view of the AS3MT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.