The protein encoded by this gene belongs to the ARG-specific ADP-ribosyltransferase family. Proteins in this family regulate the function of target proteins by attaching ADP-ribose to specific amino acid residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for ART5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ART5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ART5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:3,378,728–3,379,430 | 263.1 kb | Distal (>10kb) Multiome | 821 | |
| chr11:3,380,404–3,381,449 | 261.5 kb | Distal (>10kb) Multiome | 195 | |
| chr11:3,421,770–3,423,686 | 219.4 kb | Distal (>10kb) Multiome | 328 | |
| chr11:3,580,829–3,581,470 | 61.0 kb | Distal (>10kb) Multiome | 80 | |
| chr11:3,614,331–3,614,934 | 27.7 kb | Distal (>10kb) Multiome | 150 | |
| chr11:3,641,420–3,643,023 | 127 bp | At TSS Multiome | 679 | |
| chr11:3,649,461–3,649,679 | 7.5 kb | Proximal (<10kb) | 15 | |
| chr11:3,796,972–3,798,333 | 155.5 kb | Distal (>10kb) Multiome | 985 | |
| chr11:3,807,708–3,808,953 | 166.0 kb | Distal (>10kb) Multiome | 598 | |
| chr11:3,824,581–3,825,191 | 182.6 kb | Distal (>10kb) Multiome | 332 | |
| chr11:3,840,339–3,841,901 | 198.8 kb | Distal (>10kb) Multiome | 853 | |
| chr11:3,854,400–3,856,473 | 212.9 kb | Distal (>10kb) Multiome | 929 |
Genomic view of the ART5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.