This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for ART3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ART3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ART3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:75,848,100–75,848,739 | 226.3 kb | Distal (>10kb) Multiome | 281 | |
| chr4:75,939,639–75,941,475 | 133.7 kb | Distal (>10kb) Multiome | 762 | |
| chr4:75,990,621–75,991,159 | 83.8 kb | Distal (>10kb) Multiome HiCAR | 782 | |
| chr4:76,067,763–76,067,929 | 6.8 kb | Proximal (<10kb) | 88 | |
| chr4:76,087,045–76,087,527 | 12.6 kb | Distal (>10kb) Multiome | 438 | |
| chr4:76,147,405–76,148,870 | 73.8 kb | Distal (>10kb) Multiome | 1076 | |
| chr4:76,212,911–76,214,625 | 139.1 kb | Distal (>10kb) Multiome | 798 | |
| chr4:76,251,398–76,252,255 | 177.1 kb | Distal (>10kb) Multiome | 710 | |
| chr4:76,305,965–76,307,583 | 231.9 kb | Distal (>10kb) Multiome | 793 |
Genomic view of the ART3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.