Involved in directional locomotion; negative regulation of cell migration; and negative regulation of cellular component organization. Predicted to be located in lamellipodium. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARPIN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARPIN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARPIN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:89,654,859–89,655,986 | 257.2 kb | Distal (>10kb) Multiome | 484 | |
| chr15:89,665,508–89,666,065 | 246.9 kb | Distal (>10kb) Multiome | 279 | |
| chr15:89,690,263–89,691,125 | 222.0 kb | Distal (>10kb) Multiome | 669 | |
| chr15:89,747,326–89,748,774 | 164.7 kb | Distal (>10kb) Multiome | 214 | |
| chr15:89,750,169–89,751,978 | 161.8 kb | Distal (>10kb) Multiome | 732 | |
| chr15:89,760,201–89,761,182 | 152.0 kb | Distal (>10kb) Multiome | 473 | |
| chr15:89,775,879–89,777,425 | 136.1 kb | Distal (>10kb) Multiome | 647 | |
| chr15:89,893,669–89,894,442 | 18.6 kb | Distal (>10kb) Multiome | 1083 | |
| chr15:89,912,261–89,913,121 | 147 bp | At TSS Multiome | 514 | |
| chr15:89,999,673–90,000,089 | 87.2 kb | Distal (>10kb) Multiome | 174 | |
| chr15:90,001,237–90,002,666 | 89.1 kb | Distal (>10kb) Multiome | 589 | |
| chr15:90,061,829–90,062,285 | 149.4 kb | Distal (>10kb) Multiome HiCAR | 347 | |
| chr15:90,075,459–90,076,479 | 163.3 kb | Distal (>10kb) Multiome | 275 | |
| chr15:90,101,730–90,103,001 | 189.8 kb | Distal (>10kb) Multiome | 693 | |
| chr15:90,143,210–90,143,683 | 230.7 kb | Distal (>10kb) Multiome | 578 | |
| chr15:90,184,585–90,185,456 | 272.4 kb | Distal (>10kb) Multiome | 806 | |
| chr15:90,200,589–90,202,277 | 288.6 kb | Distal (>10kb) Multiome | 649 |
Genomic view of the ARPIN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.