Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation and cell migration. Located in extracellular exosome and focal adhesion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARPC5L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARPC5L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARPC5L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:124,769,647–124,772,472 | 90.7 kb | Distal (>10kb) Multiome HiCAR | 1006 | |
| chr9:124,776,976–124,778,058 | 84.8 kb | Distal (>10kb) Multiome HiCAR | 349 | |
| chr9:124,779,329–124,780,041 | 82.4 kb | Distal (>10kb) Multiome HiCAR | 260 | |
| chr9:124,810,709–124,811,373 | 51.1 kb | Distal (>10kb) Multiome | 209 | |
| chr9:124,839,680–124,840,329 | 22.2 kb | Distal (>10kb) Multiome | 218 | |
| chr9:124,852,683–124,853,882 | 8.9 kb | Proximal (<10kb) Multiome | 666 | |
| chr9:124,855,555–124,856,920 | 5.9 kb | Proximal (<10kb) Multiome | 402 | |
| chr9:124,861,378–124,862,662 | 69 bp | At TSS Multiome | 947 | |
| chr9:124,868,442–124,869,814 | 7.0 kb | Proximal (<10kb) Multiome | 849 | |
| chr9:124,940,496–124,941,902 | 79.0 kb | Distal (>10kb) Multiome | 979 | |
| chr9:125,142,890–125,144,084 | 281.5 kb | Distal (>10kb) Multiome | 723 |
Genomic view of the ARPC5L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.