This gene encodes a member of the ARM (armadillo/beta-catenin-like repeat) superfamily. The ARM repeat is a tandemly repeated sequence motif with approximately 40 amino acid long. This repeat is implicated in mediating protein-protein interactions. The encoded protein contains seven ARM repeats. Mutations in this gene are associated with primary bilateral macronodular adrenal hyperplasia, which is also known as ACTH-independent macronodular adrenal hyperplasia 2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Transcription factors with Perturb-seq knockdown data for ARMC5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARMC5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARMC5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:31,134,682–31,136,040 | 323.8 kb | Distal (>10kb) Multiome HiCAR | 450 | |
| chr16:31,141,455–31,143,270 | 317.1 kb | Distal (>10kb) Multiome HiCAR | 856 | |
| chr16:31,148,229–31,148,775 | 311.1 kb | Distal (>10kb) Multiome HiCAR | 209 | |
| chr16:31,179,340–31,181,495 | 279.5 kb | Distal (>10kb) Multiome | 1179 | |
| chr16:31,214,606–31,216,091 | 244.2 kb | Distal (>10kb) Multiome | 469 | |
| chr16:31,406,131–31,406,947 | 53.0 kb | Distal (>10kb) Multiome | 214 | |
| chr16:31,442,550–31,443,636 | 16.4 kb | Distal (>10kb) Multiome | 838 | |
| chr16:31,451,660–31,452,037 | 7.5 kb | Proximal (<10kb) | 408 | |
| chr16:31,455,767–31,455,940 | 3.6 kb | Proximal (<10kb) | 145 | |
| chr16:31,457,952–31,460,456 | 1.4 kb | Proximal (<10kb) Multiome | 1128 | |
| chr16:31,476,391–31,478,207 | 18.3 kb | Distal (>10kb) Multiome | 750 | |
| chr16:31,487,298–31,488,862 | 28.4 kb | Distal (>10kb) Multiome | 323 | |
| chr16:31,507,726–31,508,748 | 48.9 kb | Distal (>10kb) Multiome | 992 | |
| chr16:31,700,204–31,701,065 | 241.1 kb | Distal (>10kb) Multiome | 787 | |
| chr16:31,712,839–31,714,180 | 253.8 kb | Distal (>10kb) Multiome | 930 |
Genomic view of the ARMC5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.