This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for ARMC10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARMC10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARMC10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:102,748,441–102,749,501 | 326.1 kb | Distal (>10kb) Multiome HiCAR | 433 | |
| chr7:103,074,047–103,075,916 | 76 bp | At TSS Multiome | 860 | |
| chr7:103,078,197–103,078,458 | 3.3 kb | Proximal (<10kb) | 13 | |
| chr7:103,148,730–103,149,910 | 74.4 kb | Distal (>10kb) Multiome | 1002 | |
| chr7:103,279,769–103,280,793 | 205.5 kb | Distal (>10kb) Multiome | 291 | |
| chr7:103,297,040–103,297,853 | 222.5 kb | Distal (>10kb) Multiome | 880 | |
| chr7:103,344,148–103,345,138 | 269.8 kb | Distal (>10kb) Multiome | 994 | |
| chr7:103,347,517–103,348,162 | 272.8 kb | Distal (>10kb) Multiome | 795 |
Genomic view of the ARMC10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.