Enables GDP binding activity; GTP binding activity; and microtubule binding activity. Involved in several processes, including cilium assembly; protein localization to cilium; and small GTPase-mediated signal transduction. Acts upstream of or within post-Golgi vesicle-mediated transport. Located in several cellular components, including microtubule cytoskeleton; midbody; and photoreceptor connecting cilium. Implicated in Joubert syndrome and retinitis pigmentosa 83. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:102,418,158–102,422,381 | 294.8 kb | Distal (>10kb) Multiome | 1097 | |
| chr10:102,422,562–102,423,126 | 291.5 kb | Distal (>10kb) Multiome | 721 | |
| chr10:102,431,859–102,432,863 | 281.8 kb | Distal (>10kb) Multiome | 828 | |
| chr10:102,449,444–102,451,250 | 264.7 kb | Distal (>10kb) Multiome | 810 | |
| chr10:102,454,792–102,455,588 | 259.4 kb | Distal (>10kb) Multiome | 159 | |
| chr10:102,460,805–102,462,064 | 253.0 kb | Distal (>10kb) Multiome | 665 | |
| chr10:102,501,628–102,503,235 | 212.2 kb | Distal (>10kb) Multiome | 738 | |
| chr10:102,503,432–102,504,897 | 210.4 kb | Distal (>10kb) Multiome | 684 | |
| chr10:102,641,824–102,646,130 | 69.3 kb | Distal (>10kb) Multiome | 1123 | |
| chr10:102,678,809–102,679,295 | 35.3 kb | Distal (>10kb) Multiome | 476 | |
| chr10:102,713,669–102,715,337 | 5 bp | At TSS Multiome | 895 | |
| chr10:102,743,388–102,744,547 | 29.4 kb | Distal (>10kb) Multiome | 777 | |
| chr10:102,776,775–102,777,340 | 62.6 kb | Distal (>10kb) Multiome | 419 | |
| chr10:102,853,920–102,854,718 | 140.0 kb | Distal (>10kb) Multiome | 859 | |
| chr10:102,869,308–102,870,223 | 155.2 kb | Distal (>10kb) Multiome | 509 | |
| chr10:102,916,941–102,919,907 | 203.8 kb | Distal (>10kb) Multiome | 984 |
Genomic view of the ARL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.