ARHGEF28

Rho guanine nucleotide exchange factor 28 | RGNEF, RIP2, p190RhoGEF

This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

Biological processes 12 terms

cytoplasm (GO:0005737)cytosol (GO:0005829)ephrin receptor signaling pathway (GO:0048013)guanyl-nucleotide exchange factor activity (GO:0005085)guanyl-nucleotide exchange factor activity (GO:0005085)guanyl-nucleotide exchange factor activity (GO:0005085)guanyl-nucleotide exchange factor activity (GO:0005085)plasma membrane (GO:0005886)protein binding (GO:0005515)regulation of Rho protein signal transduction (GO:0035023)regulation of small GTPase mediated signal transduction (GO:0051056)small GTPase-mediated signal transduction (GO:0007264)

Expression (TPM)

TFs regulating ARHGEF28 0 TFs

Transcription factors with Perturb-seq knockdown data for ARHGEF28. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGEF28 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ARHGEF28

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGEF28, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr5:73,381,483–73,382,813	244.1 kb	Distal (>10kb) Multiome	174
chr5:73,419,250–73,420,167	206.4 kb	Distal (>10kb) Multiome	205
chr5:73,436,362–73,437,853	188.7 kb	Distal (>10kb) Multiome	622
chr5:73,443,832–73,444,744	181.9 kb	Distal (>10kb) Multiome	212
chr5:73,446,878–73,449,160	177.4 kb	Distal (>10kb) Multiome	568
chr5:73,497,594–73,498,924	127.7 kb	Distal (>10kb) Multiome	924
chr5:73,519,532–73,520,021	106.3 kb	Distal (>10kb) Multiome	375
chr5:73,564,957–73,566,058	60.5 kb	Distal (>10kb) Multiome	828
chr5:73,625,688–73,626,803	33 bp	At TSS Multiome	623

Genome Browser

Genomic view of the ARHGEF28 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.