ARHGEF16

Rho guanine nucleotide exchange factor 16 | GEF16, NBR

Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]

Developmental clusters: GC7

Biological processes 18 terms

GTPase activator activity (GO:0005096)PDZ domain binding (GO:0030165)activation of GTPase activity (GO:0090630)cadherin binding (GO:0045296)cell chemotaxis (GO:0060326)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)guanyl-nucleotide exchange factor activity (GO:0005085)guanyl-nucleotide exchange factor activity (GO:0005085)guanyl-nucleotide exchange factor activity (GO:0005085)positive regulation of protein localization to plasma membrane (GO:1903078)protein binding (GO:0005515)receptor tyrosine kinase binding (GO:0030971)regulation of Cdc42 protein signal transduction (GO:0032489)regulation of Cdc42 protein signal transduction (GO:0032489)regulation of actin cytoskeleton organization (GO:0032956)small GTPase binding (GO:0031267)

Expression (TPM)

TFs regulating ARHGEF16 0 TFs

Transcription factors with Perturb-seq knockdown data for ARHGEF16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGEF16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ARHGEF16

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGEF16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:1,540,164–1,541,317	1914.0 kb	Distal (>10kb) Multiome HiCAR	195
chr1:2,189,382–2,190,314	1265.0 kb	Distal (>10kb) Multiome HiCAR	719
chr1:2,194,502–2,195,788	1259.6 kb	Distal (>10kb) Multiome HiCAR	789
chr1:2,199,148–2,199,756	1255.2 kb	Distal (>10kb) Multiome HiCAR	445
chr1:2,391,076–2,392,400	1063.0 kb	Distal (>10kb) Multiome HiCAR	820
chr1:2,411,953–2,414,836	1040.2 kb	Distal (>10kb) Multiome HiCAR	918
chr1:2,525,908–2,527,142	928.2 kb	Distal (>10kb) Multiome HiCAR	668
chr1:2,545,676–2,548,580	906.4 kb	Distal (>10kb) Multiome HiCAR	918
chr1:2,585,182–2,587,696	868.0 kb	Distal (>10kb) Multiome HiCAR	748
chr1:3,453,034–3,455,700	1.4 kb	Proximal (<10kb) Multiome	874
chr1:3,471,270–3,471,995	17.0 kb	Distal (>10kb) Multiome	575
chr1:3,491,285–3,491,949	36.8 kb	Distal (>10kb) Multiome	309
chr1:3,530,504–3,532,073	76.8 kb	Distal (>10kb) Multiome	442
chr1:3,610,667–3,612,281	157.0 kb	Distal (>10kb) Multiome HiCAR	361
chr1:3,624,289–3,625,883	170.2 kb	Distal (>10kb) Multiome HiCAR	814
chr1:3,649,785–3,650,304	195.4 kb	Distal (>10kb) Multiome	620
chr1:3,651,921–3,653,136	198.1 kb	Distal (>10kb) Multiome	369
chr1:3,746,744–3,747,607	292.7 kb	Distal (>10kb) Multiome	523

Genome Browser

Genomic view of the ARHGEF16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.