This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for ARHGEF10L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGEF10L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGEF10L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:17,377,361–17,378,012 | 162.2 kb | Distal (>10kb) Multiome | 196 | |
| chr1:17,406,075–17,406,641 | 133.3 kb | Distal (>10kb) Multiome | 422 | |
| chr1:17,437,423–17,439,141 | 101.9 kb | Distal (>10kb) Multiome | 678 | |
| chr1:17,439,507–17,440,088 | 99.9 kb | Distal (>10kb) Multiome | 505 | |
| chr1:17,538,513–17,539,065 | 968 bp | At TSS Multiome | 147 | |
| chr1:17,540,729–17,541,117 | 1.0 kb | Proximal (<10kb) | 158 | |
| chr1:17,703,969–17,704,568 | 164.7 kb | Distal (>10kb) Multiome | 33 |
Genomic view of the ARHGEF10L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.