The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]
Transcription factors with Perturb-seq knockdown data for ARHGDIG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGDIG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGDIG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:52,954–54,208 | 226.9 kb | Distal (>10kb) Multiome | 950 | |
| chr16:71,378–73,062 | 209.1 kb | Distal (>10kb) Multiome | 639 | |
| chr16:77,240–78,636 | 202.5 kb | Distal (>10kb) Multiome | 685 | |
| chr16:138,551–139,186 | 141.9 kb | Distal (>10kb) Multiome | 674 | |
| chr16:180,313–181,713 | 99.1 kb | Distal (>10kb) Multiome | 994 | |
| chr16:228,869–229,598 | 51.3 kb | Distal (>10kb) Multiome | 1035 | |
| chr16:234,152–235,669 | 45.8 kb | Distal (>10kb) Multiome | 908 | |
| chr16:351,804–354,436 | 72.3 kb | Distal (>10kb) Multiome | 654 | |
| chr16:378,999–379,813 | 98.8 kb | Distal (>10kb) Multiome | 225 | |
| chr16:380,836–382,614 | 101.4 kb | Distal (>10kb) Multiome | 634 | |
| chr16:383,438–384,218 | 103.2 kb | Distal (>10kb) Multiome | 342 | |
| chr16:396,893–397,640 | 116.9 kb | Distal (>10kb) Multiome | 496 | |
| chr16:401,380–402,199 | 121.3 kb | Distal (>10kb) Multiome | 818 | |
| chr16:424,888–426,136 | 145.0 kb | Distal (>10kb) Multiome | 752 | |
| chr16:483,333–484,000 | 203.2 kb | Distal (>10kb) Multiome | 143 | |
| chr16:526,749–528,601 | 247.0 kb | Distal (>10kb) Multiome | 811 | |
| chr16:569,530–570,338 | 289.3 kb | Distal (>10kb) Multiome | 492 | |
| chr16:578,896–579,353 | 298.6 kb | Distal (>10kb) Multiome | 511 |
Genomic view of the ARHGDIG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.