Enables phospholipid binding activity. Predicted to be involved in negative regulation of Rac protein signal transduction; regulation of actin cytoskeleton organization; and regulation of plasma membrane bounded cell projection organization. Located in leading edge membrane. Implicated in acquired immunodeficiency syndrome and skin melanoma. Biomarker of hepatocellular carcinoma and lung carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARHGAP44. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP44 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP44, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:12,634,848–12,635,693 | 154.2 kb | Distal (>10kb) Multiome | 115 | |
| chr17:12,665,274–12,666,274 | 123.7 kb | Distal (>10kb) Multiome | 398 | |
| chr17:12,730,942–12,731,456 | 58.3 kb | Distal (>10kb) Multiome | 283 | |
| chr17:12,789,314–12,790,678 | 111 bp | At TSS Multiome | 524 | |
| chr17:12,973,335–12,974,358 | 184.5 kb | Distal (>10kb) Multiome | 136 | |
| chr17:13,017,268–13,018,649 | 228.6 kb | Distal (>10kb) Multiome | 828 | |
| chr17:13,024,142–13,024,931 | 235.1 kb | Distal (>10kb) Multiome | 254 |
Genomic view of the ARHGAP44 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.