Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARHGAP36. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGAP36 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGAP36, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:131,067,143–131,067,765 | 5.2 kb | Proximal (<10kb) | 160 | |
| chrX:131,068,037–131,068,807 | 4.2 kb | Proximal (<10kb) | 130 | |
| chrX:131,068,924–131,069,228 | 3.8 kb | Proximal (<10kb) | 139 | |
| chrX:131,073,233–131,073,531 | 246 bp | At TSS | 41 | |
| chrX:131,082,210–131,082,743 | 9.2 kb | Proximal (<10kb) | 71 |
Genomic view of the ARHGAP36 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.