Predicted to enable GTPase activator activity. Predicted to be involved in COPI coating of Golgi vesicle. Located in Golgi apparatus; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARFGAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARFGAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARFGAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:46,826,562–46,827,053 | 350.0 kb | Distal (>10kb) Multiome HiCAR | 529 | |
| chr11:46,912,540–46,913,271 | 264.0 kb | Distal (>10kb) Multiome HiCAR | 252 | |
| chr11:46,917,991–46,919,090 | 258.3 kb | Distal (>10kb) Multiome HiCAR | 405 | |
| chr11:46,936,572–46,937,187 | 240.1 kb | Distal (>10kb) Multiome | 744 | |
| chr11:46,947,422–46,947,958 | 229.0 kb | Distal (>10kb) Multiome | 150 | |
| chr11:47,160,949–47,161,864 | 15.4 kb | Distal (>10kb) Multiome | 322 | |
| chr11:47,176,472–47,177,856 | 168 bp | At TSS Multiome | 857 | |
| chr11:47,179,605–47,179,784 | 2.7 kb | Proximal (<10kb) | 114 | |
| chr11:47,184,866–47,187,095 | 9.6 kb | Proximal (<10kb) Multiome | 849 | |
| chr11:47,214,114–47,215,529 | 38.0 kb | Distal (>10kb) Multiome | 785 | |
| chr11:47,248,482–47,249,399 | 72.0 kb | Distal (>10kb) Multiome | 1059 | |
| chr11:47,257,299–47,258,204 | 81.0 kb | Distal (>10kb) Multiome | 519 | |
| chr11:47,259,310–47,259,960 | 82.8 kb | Distal (>10kb) Multiome | 270 | |
| chr11:47,268,988–47,270,613 | 92.9 kb | Distal (>10kb) Multiome | 884 | |
| chr11:47,354,896–47,355,720 | 178.5 kb | Distal (>10kb) Multiome HiCAR | 670 | |
| chr11:47,399,791–47,400,763 | 223.4 kb | Distal (>10kb) Multiome | 450 | |
| chr11:47,407,671–47,409,059 | 231.5 kb | Distal (>10kb) Multiome | 986 | |
| chr11:47,425,998–47,427,263 | 249.7 kb | Distal (>10kb) Multiome | 879 |
Genomic view of the ARFGAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.