This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARF6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARF6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARF6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:49,598,179–49,599,418 | 294.2 kb | Distal (>10kb) Multiome | 967 | |
| chr14:49,620,144–49,621,897 | 272.3 kb | Distal (>10kb) Multiome | 930 | |
| chr14:49,633,485–49,635,896 | 258.7 kb | Distal (>10kb) Multiome | 1040 | |
| chr14:49,687,569–49,688,718 | 204.8 kb | Distal (>10kb) Multiome | 843 | |
| chr14:49,692,914–49,693,633 | 199.8 kb | Distal (>10kb) Multiome | 764 | |
| chr14:49,767,430–49,769,102 | 125.1 kb | Distal (>10kb) Multiome | 899 | |
| chr14:49,852,270–49,853,410 | 40.3 kb | Distal (>10kb) Multiome | 813 | |
| chr14:49,853,662–49,854,089 | 39.1 kb | Distal (>10kb) Multiome | 439 | |
| chr14:49,861,592–49,863,464 | 30.2 kb | Distal (>10kb) Multiome | 1038 | |
| chr14:49,867,745–49,868,682 | 24.8 kb | Distal (>10kb) Multiome | 699 | |
| chr14:49,892,363–49,894,019 | 118 bp | At TSS Multiome | 981 | |
| chr14:50,000,183–50,001,939 | 108.3 kb | Distal (>10kb) Multiome | 669 | |
| chr14:50,116,214–50,116,984 | 223.5 kb | Distal (>10kb) Multiome HiCAR | 818 |
Genomic view of the ARF6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.