The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for APBA3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APBA3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APBA3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:3,500,403–3,501,074 | 260.9 kb | Distal (>10kb) Multiome | 886 | |
| chr19:3,505,575–3,507,061 | 255.6 kb | Distal (>10kb) Multiome | 838 | |
| chr19:3,557,019–3,558,238 | 204.0 kb | Distal (>10kb) Multiome | 811 | |
| chr19:3,572,147–3,574,664 | 189.0 kb | Distal (>10kb) Multiome | 737 | |
| chr19:3,576,363–3,578,543 | 183.4 kb | Distal (>10kb) Multiome | 346 | |
| chr19:3,606,342–3,607,177 | 154.9 kb | Distal (>10kb) Multiome | 377 | |
| chr19:3,626,518–3,627,304 | 134.7 kb | Distal (>10kb) Multiome | 833 | |
| chr19:3,699,968–3,700,899 | 61.2 kb | Distal (>10kb) Multiome | 489 | |
| chr19:3,721,462–3,721,997 | 40.1 kb | Distal (>10kb) Multiome | 760 | |
| chr19:3,722,652–3,723,093 | 38.7 kb | Distal (>10kb) Multiome | 106 | |
| chr19:3,761,103–3,762,150 | 95 bp | At TSS Multiome | 839 | |
| chr19:3,762,300–3,763,344 | 1.2 kb | Proximal (<10kb) Multiome | 817 | |
| chr19:3,786,012–3,786,456 | 24.5 kb | Distal (>10kb) Multiome | 237 | |
| chr19:3,868,451–3,869,181 | 107.3 kb | Distal (>10kb) Multiome | 233 | |
| chr19:3,932,937–3,933,664 | 171.6 kb | Distal (>10kb) Multiome | 198 | |
| chr19:3,968,623–3,969,280 | 207.2 kb | Distal (>10kb) Multiome | 547 | |
| chr19:3,970,535–3,971,713 | 209.5 kb | Distal (>10kb) Multiome | 728 | |
| chr19:3,985,032–3,985,862 | 223.8 kb | Distal (>10kb) Multiome | 932 | |
| chr19:3,987,682–3,988,217 | 226.3 kb | Distal (>10kb) Multiome | 346 | |
| chr19:4,006,992–4,008,553 | 245.9 kb | Distal (>10kb) Multiome | 888 |
Genomic view of the APBA3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.