This gene encodes a subunit of the AP3 adaptor complex. This complex functions in the formation of subcellular vesicles budded from the Golgi body. Several related pseudogenes of this gene have been found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for AP3S1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AP3S1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AP3S1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:115,543,835–115,545,478 | 297.1 kb | Distal (>10kb) Multiome | 943 | |
| chr5:115,601,724–115,602,813 | 239.8 kb | Distal (>10kb) Multiome | 542 | |
| chr5:115,625,502–115,626,687 | 215.8 kb | Distal (>10kb) Multiome | 976 | |
| chr5:115,785,567–115,786,155 | 56.1 kb | Distal (>10kb) Multiome | 90 | |
| chr5:115,815,539–115,817,207 | 25.3 kb | Distal (>10kb) Multiome | 490 | |
| chr5:115,838,984–115,839,487 | 2.4 kb | Proximal (<10kb) | 135 | |
| chr5:115,840,887–115,842,729 | 61 bp | At TSS Multiome | 1077 | |
| chr5:116,084,169–116,085,557 | 243.2 kb | Distal (>10kb) Multiome | 922 |
Genomic view of the AP3S1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.