The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for AP2B1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AP2B1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AP2B1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:35,312,777–35,313,483 | 274.3 kb | Distal (>10kb) Multiome | 263 | |
| chr17:35,448,264–35,448,971 | 138.7 kb | Distal (>10kb) Multiome | 350 | |
| chr17:35,460,343–35,460,836 | 126.7 kb | Distal (>10kb) Multiome | 174 | |
| chr17:35,567,580–35,568,368 | 19.4 kb | Distal (>10kb) Multiome | 673 | |
| chr17:35,578,257–35,578,977 | 8.7 kb | Proximal (<10kb) Multiome | 860 | |
| chr17:35,586,924–35,588,023 | 65 bp | At TSS Multiome | 932 | |
| chr17:35,596,596–35,596,886 | 9.3 kb | Proximal (<10kb) | 138 | |
| chr17:35,731,320–35,732,101 | 144.4 kb | Distal (>10kb) Multiome | 406 | |
| chr17:35,763,993–35,764,924 | 177.0 kb | Distal (>10kb) Multiome | 888 | |
| chr17:35,795,171–35,795,832 | 208.1 kb | Distal (>10kb) Multiome | 290 | |
| chr17:35,808,939–35,810,190 | 222.1 kb | Distal (>10kb) Multiome | 899 |
Genomic view of the AP2B1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.