AP2A1

adaptor related protein complex 2 subunit alpha 1 | ADTAA, CLAPA1

This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

Biological processes 54 terms

AP-2 adaptor complex (GO:0030122)AP-2 adaptor complex (GO:0030122)AP-2 adaptor complex (GO:0030122)AP-2 adaptor complex (GO:0030122)AP-2 adaptor complex (GO:0030122)Golgi to endosome transport (GO:0006895)apical plasma membrane (GO:0016324)basolateral plasma membrane (GO:0016323)clathrin adaptor complex (GO:0030131)clathrin coat of trans-Golgi network vesicle (GO:0030130)clathrin-cargo adaptor activity (GO:0035615)clathrin-cargo adaptor activity (GO:0035615)clathrin-cargo adaptor activity (GO:0035615)clathrin-coated endocytic vesicle (GO:0045334)clathrin-coated endocytic vesicle membrane (GO:0030669)clathrin-coated vesicle (GO:0030136)clathrin-dependent endocytosis (GO:0072583)clathrin-dependent endocytosis (GO:0072583)clathrin-dependent endocytosis (GO:0072583)clathrin-dependent endocytosis (GO:0072583)clathrin-dependent endocytosis (GO:0072583)clathrin-dependent endocytosis (GO:0072583)cytoplasmic side of plasma membrane (GO:0009898)cytosol (GO:0005829)endocytic vesicle membrane (GO:0030666)endocytosis (GO:0006897)endolysosome membrane (GO:0036020)endolysosome membrane (GO:0036020)filopodium tip (GO:0032433)glutamatergic synapse (GO:0098978)intracellular protein transport (GO:0006886)intracellular protein transport (GO:0006886)low-density lipoprotein particle receptor binding (GO:0050750)membrane (GO:0016020)membrane (GO:0016020)membrane coat (GO:0030117)negative regulation of hyaluronan biosynthetic process (GO:1900126)negative regulation of hyaluronan biosynthetic process (GO:1900126)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of neuron projection development (GO:0010976)positive regulation of receptor-mediated endocytosis (GO:0048260)postsynaptic endocytic zone (GO:0098843)postsynaptic neurotransmitter receptor internalization (GO:0098884)protein binding (GO:0005515)protein kinase binding (GO:0019901)protein kinase binding (GO:0019901)protein transport (GO:0015031)protein-containing complex (GO:0032991)protein-containing complex binding (GO:0044877)synaptic vesicle (GO:0008021)synaptic vesicle endocytosis (GO:0048488)vesicle-mediated transport (GO:0016192)vesicle-mediated transport (GO:0016192)

Expression (TPM)

TFs regulating AP2A1 0 TFs

Transcription factors with Perturb-seq knockdown data for AP2A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AP2A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to AP2A1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AP2A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:49,476,063–49,476,551	290.6 kb	Distal (>10kb) Multiome	244
chr19:49,487,027–49,488,279	279.6 kb	Distal (>10kb) Multiome	964
chr19:49,495,613–49,496,661	270.8 kb	Distal (>10kb) Multiome	919
chr19:49,500,403–49,501,353	266.3 kb	Distal (>10kb) Multiome	405
chr19:49,512,565–49,513,700	253.9 kb	Distal (>10kb) Multiome	655
chr19:49,527,651–49,528,221	239.1 kb	Distal (>10kb) Multiome	354
chr19:49,533,232–49,534,476	233.0 kb	Distal (>10kb) Multiome	534
chr19:49,555,629–49,557,180	210.8 kb	Distal (>10kb) Multiome	294
chr19:49,580,125–49,580,813	186.4 kb	Distal (>10kb) Multiome	848
chr19:49,589,601–49,594,008	173.5 kb	Distal (>10kb) Multiome	994
chr19:49,638,063–49,638,728	128.7 kb	Distal (>10kb) Multiome	237
chr19:49,639,671–49,642,787	126.6 kb	Distal (>10kb) Multiome	1067
chr19:49,664,165–49,665,096	102.5 kb	Distal (>10kb) Multiome	679
chr19:49,665,345–49,666,430	101.1 kb	Distal (>10kb) Multiome	721
chr19:49,672,105–49,672,787	94.6 kb	Distal (>10kb) Multiome	625
chr19:49,676,058–49,678,754	90.1 kb	Distal (>10kb) Multiome	1033
chr19:49,680,433–49,681,147	86.2 kb	Distal (>10kb) Multiome	435
chr19:49,690,485–49,691,761	75.9 kb	Distal (>10kb) Multiome	327
chr19:49,746,188–49,746,748	20.5 kb	Distal (>10kb) Multiome	283
chr19:49,765,502–49,765,940	1.1 kb	Proximal (<10kb)	414
chr19:49,766,231–49,767,440	306 bp	At TSS Multiome	718
chr19:49,802,146–49,802,787	35.5 kb	Distal (>10kb) Multiome	200
chr19:49,805,226–49,805,871	38.6 kb	Distal (>10kb) Multiome	245
chr19:49,808,201–49,809,746	41.9 kb	Distal (>10kb) Multiome	509
chr19:49,812,926–49,813,834	46.5 kb	Distal (>10kb) Multiome	650
chr19:49,817,356–49,818,721	51.2 kb	Distal (>10kb) Multiome	784
chr19:49,850,394–49,852,067	83.9 kb	Distal (>10kb) Multiome	862
chr19:49,866,817–49,868,124	100.4 kb	Distal (>10kb) Multiome	874
chr19:49,869,068–49,870,398	102.6 kb	Distal (>10kb) Multiome	832
chr19:49,875,842–49,878,576	110.8 kb	Distal (>10kb) Multiome	1153
chr19:49,889,853–49,891,381	123.5 kb	Distal (>10kb) Multiome	640
chr19:49,928,884–49,930,473	162.9 kb	Distal (>10kb) Multiome	1141
chr19:49,987,157–49,987,669	220.3 kb	Distal (>10kb) Multiome	1095
chr19:50,024,875–50,026,285	258.7 kb	Distal (>10kb) Multiome	1137

Genome Browser

Genomic view of the AP2A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.