The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for AP1M1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AP1M1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AP1M1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:15,113,323–15,113,828 | 1084.3 kb | Distal (>10kb) Multiome HiCAR | 116 | |
| chr19:15,124,546–15,126,107 | 1072.2 kb | Distal (>10kb) Multiome HiCAR | 949 | |
| chr19:15,180,886–15,181,623 | 1016.7 kb | Distal (>10kb) Multiome HiCAR | 355 | |
| chr19:15,432,448–15,433,787 | 765.1 kb | Distal (>10kb) Multiome HiCAR | 766 | |
| chr19:16,075,837–16,077,586 | 121.5 kb | Distal (>10kb) Multiome | 735 | |
| chr19:16,110,632–16,112,318 | 86.3 kb | Distal (>10kb) Multiome | 866 | |
| chr19:16,184,971–16,186,029 | 12.6 kb | Distal (>10kb) Multiome | 658 | |
| chr19:16,197,472–16,198,501 | 43 bp | At TSS Multiome | 806 | |
| chr19:16,247,463–16,247,928 | 49.8 kb | Distal (>10kb) Multiome | 370 | |
| chr19:16,324,466–16,326,401 | 128.2 kb | Distal (>10kb) Multiome | 477 | |
| chr19:16,471,332–16,472,638 | 274.1 kb | Distal (>10kb) Multiome | 645 | |
| chr19:16,495,870–16,496,694 | 298.3 kb | Distal (>10kb) Multiome | 780 |
Genomic view of the AP1M1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.