Transcription factors with Perturb-seq knockdown data for ANXA2R-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANXA2R-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANXA2R-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:42,811,575–42,812,593 | 230.0 kb | Distal (>10kb) Multiome | 702 | |
| chr5:42,813,381–42,813,999 | 228.4 kb | Distal (>10kb) Multiome | 122 | |
| chr5:42,893,601–42,894,516 | 148.1 kb | Distal (>10kb) Multiome | 155 | |
| chr5:42,908,461–42,909,511 | 133.1 kb | Distal (>10kb) Multiome | 451 | |
| chr5:43,017,299–43,018,875 | 24.1 kb | Distal (>10kb) Multiome | 870 | |
| chr5:43,024,983–43,026,034 | 16.6 kb | Distal (>10kb) Multiome | 130 | |
| chr5:43,033,756–43,034,480 | 7.8 kb | Proximal (<10kb) | 72 | |
| chr5:43,038,347–43,038,852 | 3.4 kb | Proximal (<10kb) | 203 | |
| chr5:43,039,430–43,041,066 | 1.2 kb | Proximal (<10kb) | 830 | |
| chr5:43,041,652–43,043,529 | at TSS | At TSS | 897 | |
| chr5:43,044,193–43,044,964 | 1.9 kb | Proximal (<10kb) | 122 | |
| chr5:43,045,375–43,045,565 | 3.1 kb | Proximal (<10kb) | 42 | |
| chr5:43,064,252–43,065,217 | 22.8 kb | Distal (>10kb) Multiome | 959 | |
| chr5:43,105,415–43,106,204 | 63.7 kb | Distal (>10kb) Multiome | 820 | |
| chr5:43,120,453–43,122,435 | 79.3 kb | Distal (>10kb) Multiome | 1097 | |
| chr5:43,312,549–43,314,340 | 271.5 kb | Distal (>10kb) Multiome | 954 |
Genomic view of the ANXA2R-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.