This gene is a member of the muscle ankyrin repeat protein (MARP) family and encodes a protein with four tandem ankyrin-like repeats. The protein is localized to the nucleus, functioning as a transcriptional regulator. Expression of this protein is induced during recovery following starvation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ANKRD23. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKRD23 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKRD23, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:96,637,810–96,638,901 | 219.6 kb | Distal (>10kb) Multiome | 1144 | |
| chr2:96,739,549–96,740,363 | 117.8 kb | Distal (>10kb) Multiome | 708 | |
| chr2:96,760,354–96,761,531 | 97.1 kb | Distal (>10kb) Multiome | 776 | |
| chr2:96,762,598–96,764,653 | 94.9 kb | Distal (>10kb) Multiome | 406 | |
| chr2:96,815,434–96,817,859 | 41.7 kb | Distal (>10kb) Multiome | 926 | |
| chr2:96,857,099–96,859,416 | 207 bp | At TSS Multiome | 1033 | |
| chr2:96,868,320–96,870,552 | 12.2 kb | Distal (>10kb) Multiome | 907 | |
| chr2:96,881,325–96,881,826 | 23.7 kb | Distal (>10kb) Multiome | 188 | |
| chr2:96,951,012–96,951,489 | 93.4 kb | Distal (>10kb) Multiome HiCAR | 450 |
Genomic view of the ANKRD23 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.