Transcription factors with Perturb-seq knockdown data for ANKRD10-IT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKRD10-IT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKRD10-IT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:110,615,145–110,616,475 | 283.6 kb | Distal (>10kb) Multiome | 792 | |
| chr13:110,644,706–110,645,508 | 254.1 kb | Distal (>10kb) Multiome | 290 | |
| chr13:110,705,702–110,706,922 | 192.9 kb | Distal (>10kb) Multiome | 770 | |
| chr13:110,712,027–110,716,477 | 183.6 kb | Distal (>10kb) Multiome | 1162 | |
| chr13:110,812,187–110,813,068 | 86.5 kb | Distal (>10kb) Multiome | 129 | |
| chr13:110,908,617–110,908,976 | 9.4 kb | Proximal (<10kb) | 228 | |
| chr13:110,914,077–110,916,083 | 16.2 kb | Distal (>10kb) Multiome | 897 | |
| chr13:111,067,321–111,068,017 | 168.4 kb | Distal (>10kb) Multiome | 435 | |
| chr13:111,114,556–111,116,153 | 215.9 kb | Distal (>10kb) Multiome | 307 | |
| chr13:111,153,132–111,154,457 | 254.5 kb | Distal (>10kb) Multiome | 911 |
Genomic view of the ANKRD10-IT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.