Enables enzyme binding activity and low-density lipoprotein particle receptor binding activity. Involved in regulation of protein-containing complex assembly. Located in 3M complex; cytosol; and membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ANKRA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKRA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKRA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:73,298,965–73,299,493 | 266.4 kb | Distal (>10kb) Multiome | 195 | |
| chr5:73,303,035–73,304,047 | 262.0 kb | Distal (>10kb) Multiome | 200 | |
| chr5:73,381,483–73,382,813 | 183.6 kb | Distal (>10kb) Multiome | 174 | |
| chr5:73,419,250–73,420,167 | 145.9 kb | Distal (>10kb) Multiome | 205 | |
| chr5:73,436,362–73,437,853 | 128.1 kb | Distal (>10kb) Multiome | 622 | |
| chr5:73,443,832–73,444,744 | 121.3 kb | Distal (>10kb) Multiome | 212 | |
| chr5:73,446,878–73,449,160 | 116.9 kb | Distal (>10kb) Multiome | 568 | |
| chr5:73,451,190–73,451,907 | 114.1 kb | Distal (>10kb) Multiome | 413 | |
| chr5:73,497,594–73,498,924 | 67.2 kb | Distal (>10kb) Multiome | 924 | |
| chr5:73,519,532–73,520,021 | 45.8 kb | Distal (>10kb) Multiome | 375 | |
| chr5:73,564,957–73,566,058 | 2 bp | At TSS Multiome | 828 | |
| chr5:73,625,688–73,626,803 | 60.5 kb | Distal (>10kb) Multiome | 623 | |
| chr5:73,795,627–73,796,633 | 230.4 kb | Distal (>10kb) Multiome | 254 |
Genomic view of the ANKRA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.