ANKLE1

ankyrin repeat and LEM domain containing 1 | FLJ39369, LEMD6, ANKRD41

Enables endonuclease activity. Involved in DNA damage response and protein export from nucleus. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 29 terms

DNA damage response (GO:0006974)DNA endonuclease activity (GO:0004520)DNA endonuclease activity (GO:0004520)DNA endonuclease activity (GO:0004520)cobalt ion binding (GO:0050897)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)double-strand break repair via homologous recombination (GO:0000724)endonuclease activity (GO:0004519)endonuclease activity (GO:0004519)magnesium ion binding (GO:0000287)manganese ion binding (GO:0030145)midbody (GO:0030496)midbody (GO:0030496)negative regulation of mitotic recombination (GO:0045950)nucleic acid metabolic process (GO:0090304)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein export from nucleus (GO:0006611)protein export from nucleus (GO:0006611)regulation of lymphoid progenitor cell differentiation (GO:1905456)regulation of myeloid progenitor cell differentiation (GO:1905453)resolution of meiotic recombination intermediates (GO:0000712)

Expression (TPM)

TFs regulating ANKLE1 0 TFs

Transcription factors with Perturb-seq knockdown data for ANKLE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANKLE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ANKLE1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANKLE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:17,074,934–17,076,532	206.3 kb	Distal (>10kb) Multiome	890
chr19:17,209,430–17,210,427	72.1 kb	Distal (>10kb) Multiome	245
chr19:17,215,005–17,215,979	66.4 kb	Distal (>10kb) Multiome	897
chr19:17,225,705–17,226,889	55.6 kb	Distal (>10kb) Multiome	870
chr19:17,234,748–17,236,650	46.8 kb	Distal (>10kb) Multiome	612
chr19:17,244,882–17,247,104	35.8 kb	Distal (>10kb) Multiome	862
chr19:17,247,935–17,248,860	33.3 kb	Distal (>10kb) Multiome	588
chr19:17,266,931–17,267,755	14.7 kb	Distal (>10kb) Multiome	720
chr19:17,281,537–17,283,120	58 bp	At TSS Multiome	669
chr19:17,289,587–17,289,821	7.7 kb	Proximal (<10kb)	128
chr19:17,292,242–17,293,049	10.8 kb	Distal (>10kb) Multiome	513
chr19:17,302,721–17,303,771	21.5 kb	Distal (>10kb) Multiome	636
chr19:17,305,286–17,306,514	23.8 kb	Distal (>10kb) Multiome	947
chr19:17,309,159–17,310,151	27.6 kb	Distal (>10kb) Multiome	741
chr19:17,327,532–17,329,548	46.1 kb	Distal (>10kb) Multiome	370
chr19:17,334,287–17,335,052	52.9 kb	Distal (>10kb) Multiome	870
chr19:17,336,574–17,338,240	55.6 kb	Distal (>10kb) Multiome	924
chr19:17,340,311–17,341,226	58.8 kb	Distal (>10kb) Multiome	419
chr19:17,390,414–17,391,521	109.2 kb	Distal (>10kb) Multiome	615
chr19:17,403,087–17,404,355	121.6 kb	Distal (>10kb) Multiome	211
chr19:17,419,503–17,420,821	138.0 kb	Distal (>10kb) Multiome	869
chr19:17,424,865–17,425,411	143.2 kb	Distal (>10kb) Multiome	328
chr19:17,448,174–17,448,841	166.7 kb	Distal (>10kb) Multiome	392
chr19:17,488,739–17,489,689	207.2 kb	Distal (>10kb) Multiome	381
chr19:17,511,113–17,512,592	230.4 kb	Distal (>10kb) Multiome	1021
chr19:17,538,878–17,540,353	258.0 kb	Distal (>10kb) Multiome	725
chr19:17,555,194–17,556,523	273.6 kb	Distal (>10kb) Multiome	713
chr19:17,576,463–17,577,455	295.0 kb	Distal (>10kb) Multiome	236
chr19:17,579,580–17,580,242	298.0 kb	Distal (>10kb) Multiome	281

Genome Browser

Genomic view of the ANKLE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.