Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ANGPTL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANGPTL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANGPTL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:126,860,094–126,861,384 | 262.1 kb | Distal (>10kb) Multiome | 736 | |
| chr9:126,914,361–126,916,118 | 207.7 kb | Distal (>10kb) Multiome | 602 | |
| chr9:127,111,996–127,112,450 | 10.4 kb | Distal (>10kb) Multiome | 160 | |
| chr9:127,122,192–127,123,298 | 201 bp | At TSS Multiome | 426 | |
| chr9:127,129,382–127,130,064 | 6.7 kb | Proximal (<10kb) | 117 | |
| chr9:127,199,063–127,199,676 | 76.7 kb | Distal (>10kb) Multiome | 315 | |
| chr9:127,223,725–127,226,151 | 102.1 kb | Distal (>10kb) Multiome | 713 | |
| chr9:127,244,905–127,245,629 | 122.6 kb | Distal (>10kb) Multiome | 447 | |
| chr9:127,396,281–127,398,388 | 274.3 kb | Distal (>10kb) Multiome | 843 |
Genomic view of the ANGPTL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.