The protein encoded by this gene is important in purine metabolism by converting AMP to IMP. The encoded protein, which acts as a homotetramer, is one of three AMP deaminases found in mammals. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Transcription factors with Perturb-seq knockdown data for AMPD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AMPD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AMPD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:109,397,369–109,398,671 | 221.8 kb | Distal (>10kb) Multiome | 654 | |
| chr1:109,425,842–109,427,054 | 193.3 kb | Distal (>10kb) Multiome | 922 | |
| chr1:109,466,294–109,467,385 | 153.2 kb | Distal (>10kb) Multiome | 452 | |
| chr1:109,483,147–109,484,806 | 135.9 kb | Distal (>10kb) Multiome | 1031 | |
| chr1:109,493,695–109,494,597 | 125.7 kb | Distal (>10kb) Multiome | 842 | |
| chr1:109,498,180–109,498,608 | 121.4 kb | Distal (>10kb) Multiome | 178 | |
| chr1:109,509,196–109,510,011 | 110.2 kb | Distal (>10kb) Multiome | 448 | |
| chr1:109,532,157–109,533,159 | 87.1 kb | Distal (>10kb) Multiome | 517 | |
| chr1:109,548,385–109,549,096 | 71.2 kb | Distal (>10kb) Multiome | 855 | |
| chr1:109,619,434–109,621,357 | 102 bp | At TSS Multiome | 814 | |
| chr1:109,643,342–109,643,856 | 23.7 kb | Distal (>10kb) Multiome | 470 | |
| chr1:109,655,698–109,656,566 | 36.3 kb | Distal (>10kb) Multiome | 707 | |
| chr1:109,667,812–109,668,362 | 48.2 kb | Distal (>10kb) Multiome | 287 | |
| chr1:109,739,695–109,740,873 | 120.5 kb | Distal (>10kb) Multiome | 633 | |
| chr1:109,877,325–109,877,790 | 257.6 kb | Distal (>10kb) Multiome | 378 | |
| chr1:109,910,465–109,911,472 | 291.0 kb | Distal (>10kb) Multiome | 618 |
Genomic view of the AMPD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.