Transcription factors with Perturb-seq knockdown data for ALOXE3P1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALOXE3P1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALOXE3P1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:8,057,766–8,057,987 | 5.9 kb | Proximal (<10kb) | 261 | |
| chr17:8,061,983–8,062,254 | 1.7 kb | Proximal (<10kb) | 13 | |
| chr17:8,068,609–8,069,844 | 4.7 kb | Proximal (<10kb) | 100 | |
| chr17:8,073,482–8,073,930 | 9.5 kb | Proximal (<10kb) | 267 |
Genomic view of the ALOXE3P1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.