ALOX15B

arachidonate 15-lipoxygenase type B | 15-LOX-2

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Biological processes 59 terms

adherens junction (GO:0005912)adherens junction (GO:0005912)apoptotic process (GO:0006915)arachidonate 15-lipoxygenase activity (GO:0050473)arachidonate 15-lipoxygenase activity (GO:0050473)arachidonate 15-lipoxygenase activity (GO:0050473)arachidonate 8(S)-lipoxygenase activity (GO:0036403)arachidonate metabolic process (GO:0019369)arachidonate metabolic process (GO:0019369)arachidonate metabolic process (GO:0019369)calcium ion binding (GO:0005509)cannabinoid biosynthetic process (GO:1901696)cytoskeleton (GO:0005856)cytoskeleton (GO:0005856)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)endocannabinoid signaling pathway (GO:0071926)extracellular exosome (GO:0070062)focal adhesion (GO:0005925)focal adhesion (GO:0005925)hepoxilin biosynthetic process (GO:0051122)hepoxilin biosynthetic process (GO:0051122)iron ion binding (GO:0005506)iron ion binding (GO:0005506)linoleate 13S-lipoxygenase activity (GO:0016165)linoleate 9S-lipoxygenase activity (GO:1990136)linoleic acid metabolic process (GO:0043651)linoleic acid metabolic process (GO:0043651)lipid metabolic process (GO:0006629)lipid metabolic process (GO:0006629)lipid oxidation (GO:0034440)lipid oxidation (GO:0034440)lipoxin A4 biosynthetic process (GO:2001303)lipoxygenase pathway (GO:0019372)lipoxygenase pathway (GO:0019372)membrane (GO:0016020)membrane (GO:0016020)metal ion binding (GO:0046872)negative regulation of cell cycle (GO:0045786)negative regulation of cell migration (GO:0030336)negative regulation of cell population proliferation (GO:0008285)negative regulation of cell population proliferation (GO:0008285)negative regulation of growth (GO:0045926)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702)phospholipid metabolic process (GO:0006644)phospholipid metabolic process (GO:0006644)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of chemokine production (GO:0032722)positive regulation of keratinocyte differentiation (GO:0045618)positive regulation of macrophage derived foam cell differentiation (GO:0010744)positive regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035360)prostate gland development (GO:0030850)protein binding (GO:0005515)regulation of epithelial cell differentiation (GO:0030856)

Expression (TPM)