ALOX15
arachidonate 15-lipoxygenase | 15-LOX-1

This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]

Biological processes 74 terms
apoptotic cell clearance (GO:0043277)apoptotic cell clearance (GO:0043277)arachidonate 12(S)-lipoxygenase activity (GO:0004052)arachidonate 12(S)-lipoxygenase activity (GO:0004052)arachidonate 12(S)-lipoxygenase activity (GO:0004052)arachidonate 15-lipoxygenase activity (GO:0050473)arachidonate 15-lipoxygenase activity (GO:0050473)arachidonate 15-lipoxygenase activity (GO:0050473)arachidonate 15-lipoxygenase activity (GO:0050473)arachidonate 15-lipoxygenase activity (GO:0050473)arachidonate metabolic process (GO:0019369)arachidonate metabolic process (GO:0019369)arachidonate metabolic process (GO:0019369)arachidonate metabolic process (GO:0019369)bone mineralization (GO:0030282)cellular response to calcium ion (GO:0071277)cellular response to interleukin-13 (GO:0035963)cytoplasm (GO:0005737)cytoplasmic side of plasma membrane (GO:0009898)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)fatty acid oxidation (GO:0019395)hepoxilin biosynthetic process (GO:0051122)inflammatory response (GO:0006954)iron ion binding (GO:0005506)iron ion binding (GO:0005506)linoleate 13S-lipoxygenase activity (GO:0016165)linoleate 13S-lipoxygenase activity (GO:0016165)linoleate 13S-lipoxygenase activity (GO:0016165)linoleic acid metabolic process (GO:0043651)linoleic acid metabolic process (GO:0043651)lipid droplet (GO:0005811)lipid droplet (GO:0005811)lipid metabolic process (GO:0006629)lipid oxidation (GO:0034440)lipid oxidation (GO:0034440)lipoxin A4 biosynthetic process (GO:2001303)lipoxin A4 biosynthetic process (GO:2001303)lipoxin biosynthetic process (GO:2001301)lipoxygenase pathway (GO:0019372)lipoxygenase pathway (GO:0019372)lipoxygenase pathway (GO:0019372)lipoxygenase pathway (GO:0019372)long-chain fatty acid biosynthetic process (GO:0042759)long-chain fatty acid biosynthetic process (GO:0042759)membrane (GO:0016020)metal ion binding (GO:0046872)negative regulation of adaptive immune response (GO:0002820)negative regulation of adaptive immune response (GO:0002820)ossification (GO:0001503)oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702)phosphatidylethanolamine biosynthetic process (GO:0006646)phosphatidylethanolamine biosynthetic process (GO:0006646)phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of ERK1 and ERK2 cascade (GO:0070374)positive regulation of actin filament polymerization (GO:0030838)positive regulation of actin filament polymerization (GO:0030838)positive regulation of cell-substrate adhesion (GO:0010811)protein binding (GO:0005515)regulation of engulfment of apoptotic cell (GO:1901074)regulation of engulfment of apoptotic cell (GO:1901074)regulation of inflammatory response (GO:0050727)regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)response to endoplasmic reticulum stress (GO:0034976)response to endoplasmic reticulum stress (GO:0034976)wound healing (GO:0042060)wound healing (GO:0042060)
Expression (TPM)
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