This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel. [provided by RefSeq, Jan 2010]
Transcription factors with Perturb-seq knockdown data for ALG10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALG10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALG10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:32,754,967–32,756,883 | 1267.2 kb | Distal (>10kb) Multiome HiCAR | 978 | |
| chr12:32,893,054–32,894,062 | 1129.2 kb | Distal (>10kb) Multiome HiCAR | 249 | |
| chr12:32,896,168–32,897,592 | 1125.6 kb | Distal (>10kb) Multiome HiCAR | 653 | |
| chr12:33,182,169–33,183,785 | 839.7 kb | Distal (>10kb) Multiome HiCAR | 136 | |
| chr12:33,438,371–33,440,222 | 582.7 kb | Distal (>10kb) Multiome HiCAR | 377 | |
| chr12:34,016,478–34,016,635 | 5.9 kb | Proximal (<10kb) | 6 | |
| chr12:34,022,100–34,023,125 | 88 bp | At TSS Multiome | 645 |
Genomic view of the ALG10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.