The enzyme encoded by this gene catalyzes the first mannosylation step in the biosynthesis of lipid-linked oligosaccharides. This gene is mutated in congenital disorder of glycosylation type Ik. [provided by RefSeq, Dec 2008]
Transcription factors with Perturb-seq knockdown data for ALG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:4,733,836–4,735,221 | 299.3 kb | Distal (>10kb) Multiome | 858 | |
| chr16:4,766,728–4,767,628 | 266.5 kb | Distal (>10kb) Multiome | 795 | |
| chr16:4,768,438–4,769,162 | 264.9 kb | Distal (>10kb) Multiome | 677 | |
| chr16:4,801,836–4,803,175 | 231.4 kb | Distal (>10kb) Multiome | 743 | |
| chr16:4,846,559–4,848,209 | 186.3 kb | Distal (>10kb) Multiome | 803 | |
| chr16:4,936,143–4,937,673 | 96.4 kb | Distal (>10kb) Multiome | 655 | |
| chr16:4,943,173–4,943,813 | 90.3 kb | Distal (>10kb) Multiome | 609 | |
| chr16:4,957,489–4,958,782 | 75.6 kb | Distal (>10kb) Multiome | 802 | |
| chr16:5,010,592–5,011,132 | 22.9 kb | Distal (>10kb) Multiome | 136 | |
| chr16:5,033,461–5,034,081 | 185 bp | At TSS Multiome | 932 | |
| chr16:5,035,406–5,035,666 | 1.7 kb | Proximal (<10kb) | 371 | |
| chr16:5,036,959–5,037,100 | 3.3 kb | Proximal (<10kb) | 172 | |
| chr16:5,071,693–5,072,259 | 38.2 kb | Distal (>10kb) Multiome | 940 | |
| chr16:5,097,069–5,098,979 | 64.4 kb | Distal (>10kb) Multiome | 638 | |
| chr16:5,213,262–5,213,748 | 179.7 kb | Distal (>10kb) Multiome | 34 | |
| chr16:5,239,557–5,240,083 | 206.0 kb | Distal (>10kb) Multiome | 57 |
Genomic view of the ALG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.